FINAL ACCEPTED VERSION Alterations in Rat Coronary Vasoreactivity and Vascular Protein Kinase C Isoforms in Type I Diabetes
نویسندگان
چکیده
منابع مشابه
Alterations in rat coronary vasoreactivity and vascular protein kinase C isoforms in Type 1 diabetes.
Vascular complications associated with diabetes mellitus (DM) have been linked to activation of PKC-dependent signaling pathways in both human and animal models of DM. To determine whether aberrant PKC signaling mechanisms specifically impact the coronary circulation, we assessed isolated coronary artery (CA) responses after the induction of Type 1 DM. Male Sprague-Dawley rats were subjected to...
متن کاملEffects of lipopolysaccharide-induced septic shock on rat isolated kidney, possible role of nitric oxide and protein kinase C pathways
Objective(s): Pathophysiology of sepsis-associated renal failure (one of the most common cause of death in intensive care units) had not been fully determined. The effect of nitric oxide and protein kinase C (PKC) pathways in isolated kidney of Lipopolysaccharide-treated (LPS) rats were investigated in this study. Materials and Methods: Vascular responsiveness to phenylephrine and acetylcholine...
متن کاملEVALUATION OF SERUM CHITINASE-3 LIKE 1 PROTEIN AND C-REACTIVE PROTEIN LEVELS IN TYPE 2 DIABETES MELLITUS WITH CORONARY ARTERY DISEASE COMPARED TO DIABETIC AND HEALTHY CONTROL
Background: Diabetes mellitus, which is associated with elevated blood glucose, lipids and liver enzymes, may results in alterations in the production of inflammatory cytokines, including chitinase-3-like protein 1 (YKL-40) and high-sensitivity C-reactive protein (hs-CRP), which induce and promote complications of diabetes such as atherosclerosis.The aim of this study was to evaluate the serum ...
متن کاملThe Effect of Eight Weeks Aerobic and Resistance Training on AMP-Activated Protein Kinase (AMPK) Gene Expression in Soleus Muscle and Insulin Resistance of STZ-Induced Diabetic Rat
Background: AMPK regulation is one of biggest target in T2D and metabolic syndrome research. Therefore, the present study is aimed to investigate The effect of 8 weeks aerobic and Resistance training on AMP-activated protein kinase (AMPK) gene expression in soleus muscle and insulin resistance of STZ-induced diabetic rat. Methods: The research method of present study was experimental. For this...
متن کاملPULMONARY VASCULAR MUSCLE PROLIFERATION AS A RESULT OF PROTEIN AND mRNA-eNOS ALTERATIONS IN A RAT MODEL OF CHF
Endothelial Nitric Oxide Synthase (eNOS) produces nitric oxide (NO) from L-arginine and is important for the maintenance of cardiovascular homeostasis. Congestive heart failure (CHF) generally results in increased pulmonary blood flow and if untreated leads to pulmonary hypertension and end stage heart failure. We therefore hypothesized that increased pulmonary flow without changes in pres...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2003